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What is Low Dose Naltroxene?

Low Dose Naltroxene (LDN) is a safe, non-toxic, and inexpensive drug that helps regulate a dysfunctional immune system. It reduces pain, and fights inflammation. It is used to treat cancers, autoimmune diseases, chronic pain and mental health issues, to name a few. Treatment is constantly evolving, with new conditions and methods of treatment being shared regularly.

How Low Dose Naltroxene (LDN) Works

Low Dose naltrexone works by re-regulating a hyperactive immune system and making it function more normally by increasing immune system receptor response to naturally circulating endorphins and neurotransmitters such as dopamine, epinephrine, norepinephrine and serotonin. LDN is a competitive opioid receptor antagonist. At the standard dose, naltrexone blocks the effects of both the endogenous opioids, which are in endorphins and pharmaceutical opioids. LDN is a pure antagonist, which is vital to know as a lot of people think it is a controlled medicine, narcotic or an opioid.

LDN is a pure inhibitor, so there is no narcotic effect. The chemical structure is almost identical to endorphins that we make naturally called met-enkephalin, also known as OGF or Opioid Growth Factor.

LDN is an antagonist at the OGF receptors and there are OGF receptors on a wide range of cells in the body.  When we talk about low dose naltrexone we mean doses that are a 10th or less of the standard dose of Naltrexone. Most of the research studies have used 4.5mg per day. Doses range from 0.001mg – 16mg in clinical practice.

Low Dose Naltrexone binds to the endorphin receptors for about 1 – 1/2 hours, and the blockade lasts about 4 - 6 hours. The effects of LDN are analgesia and anti-inflammatory.  One of the other effects is that it increases the production of your own endorphins.

What is LDN Used to Treat?

LDN is used to treat some autoimmune disease or cancer and for certain types of neuropathic pain. LDN also has general anti-inflammatory and anti-tumor effects which have been demonstrated in public literature.


Conditions Where LDN Can Be Beneficial

  • Multiple Sclerosis

  •  Lyme Disease

  •  Hashimotos

  •  Parkinson's Disease

  •  CFS/ME

  •  Chronic Regional Pain

  •  Nerve Pain

  •  Autoimmune Arthritis

  •  Crohn's Disease

  •  IBS

  •  Autoimmune Hepatitis

  • Diabetes Type 1

  • Cardiac (Heart) Diseases

  • Psoriasis

  • Melanoma

  • Lymphoma

  • Anxiety

  • Depression


  • Fertility

  • Vitiligo

  • Scleroderma

  • Glioblastoma

  • Non Small Cell Lung Cancer

  • Esophageal and Oral Cancer

  • Breast Cancer

  • Multiple Myeloma

  • Ovarian Cancer

  • Pancreatic Cancer

  • Renal Cell Cancer

  • Colorectal Cancer

  • Duodenal and Stomach Cancer

  • Uterine Cancer

  • Hepatic Cancer

  • PCOS



The summary of 10 years of research is that LDN works because:

Levo-Naltrexone is an antagonist for the opiate/endorphin receptors

  • This causes increased endorphin release

  • Increased endorphins modulate the immune response

  • This reduces the speed of unwanted cells growing. Dextro-Naltrexone is an antagonist for at least one, if not more immune cells

  • Antagonises “TLR,” suppressing cytokine modulated immune system

  • Antagonises TLR-mediated production of NF-kB – reducing inflammation, potentially downregulating oncogenes

Taking Naltrexone in larger doses of 50-300mg seems to negate the immunomodulatory effect by overwhelming the receptors, so for the effect to work, the dose must be in the range of 0.5-10mg, usually maxing at 4.5mg in clinical experience.

Getting Started

Getting started with Low Dose Naltroxene is easy. Give us a call or click the button below to schedule a consultation to discuss your symptoms and health goals and schedule a lab test. 


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